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Supplementation With Beetroot Juice to Prevent Contrast Associated Nephropathy During Hospitalization for Acute Coronary Syndrome Without ST Elevation

RecruitingNAAges 18 Years - anyAllHospital General Universitario Santa Lucia
NCT06695429 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this study is to compare the possible beneficial effect of beetroot juice supplementation versus the usual management during hospitalization to prevent contrast-induced nephropathy after cardiac catheterizations. The study includes patients diagnosed with non-ST elevation acute coronary syndrome with a possible indication for catheterism and high risk of kidney injury related to iodinated contrast. The intervention group will drink 500 mL (2 glasses daily, at breakfast and dinner) of beetroot juice added to the usual diet for 7 days or until hospital discharge and will receive the recommendation to maintain a diet rich in inorganic nitrates. The control group will receive the usual diet and recommendations. In both cases, other therapies will be prescribed to prevent contrast-induced nephropathy (hydration and statins) if there is no contraindication. Our hypothesis is tha

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📋 Eligibility rules (as published)
Inclusion Criteria: * Diagnosis of Acute Coronary Syndrome without persistent ST segment elevation, with recommendation for invasive management according to the actual Clinical practice guidelines * At least moderate or high risk of nephropathy associated with iodinated contrast (Mehran score (without including contrast volume) ≥ 6). Exclusion Criteria: * \<18 years old or without capacity to give consent. * Refusal to participate in the study. * Known hypersensitivity to beetroot or any of its allergens. * Pregnant. * Inability to take food orally * Serious illnesses (not related to ACS or kidney failure), which limits their life expectancy to a period predictably less than 1 year. * On dialysis or predialysis at the time of inclusion. * ACS with persistent ST segment elevation before inclusion. * Shock or inotrope dependence at the time of inclusion * PCI already performed before inclusion. * Patients receiving intravenous nitroglycerin for \> 1 hour before inclusion
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What it tests

  • Beetroot juice
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Where

1 site
Hospital Universitario Santa Lucía
Cartagena, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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