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AYLo - AutoimmunitY and Loss of y

Recruitingn/aAges 50 Years - anyMaleUniversity of Bonn
NCT06696027 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The AYLo study (AutoimmunitY and Loss of y - Investigating the Role of Hematopoietic Mutations and Mosaic Mutation in the Y Chromosome in Autoimmune Rheumatologic Diseases) aims to systematically investigate hematopoietic mutations, such as hematopoietic (mosaic) loss of the Y chromosome (mLOY), focusing on their underlying causes, pathophysiological significance, patterns of manifestation, and impact on disease progression in autoimmune, rheumatologic disorders. This research seeks to bridge existing knowledge gaps by exploring how such mutations influence immune homeostasis, cellular function, and susceptibility to inflammation-driven pathologies. Through the integration of advanced immunological profiling, the study aspires to uncover key mechanisms that drive the initiation, progression, and complications of autoimmune rheumatic diseases. These analyses will combine single nucleotid

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male * \> 50 years * Diagnosis of arthritis (RA, PsA), collagen diseases (SLE, systemic sclerosis, Sjögren's syndrome, mixed connective tissue diseases), vasculitis (eGPA, GPA, MPA, IgG4-related disease, GCA, PMR), sarcoidosis, COPD, ILD or asthma bronchiale confirmed by the treating physician. Exclusion Criteria: * Female * \< 50 years Inclusion Criteria (Healthy controls): * Male * \> 50 years Exclusion Criteria (Healthy controls): * Female * \< 50 years * autoimmune, rheumatological diease * pulmonary precondition
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What it tests

  • Single nucleotide polymorphisms (SNP)
  • 3'mRNA sequencing
  • Enzyme-linked immunosorbent assay (ELISA) and Legendplex Array
  • Flow Cytometry
  • Laboratory assessment
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Where

1 site
Department of Rheumatology
Bonn, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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