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Evaluation of a Long Versus Short Clomid Protocol for Controlled Ovarian Stimulation

RecruitingPhase 4Ages 18 Years - 44 YearsFemaleUniversity of Southern California
NCT06701071 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to evaluate a long Clomid protocol as compared to a 5-day Clomid protocol for ovarian stimulation in patients with diminished ovarian reserve undergoing ovarian stimulation for in-vitro fertilization. The aim of the long Clomid protocol is to intensify stimulation of the ovaries and reduce both cost and injection burden for patients. Participants will be randomized to receive the long Clomid protocol vs. the typical protocol involving Clomid only for 5 days followed by growth hormone-releasing hormone (GnRH) antagonist. The primary outcome the investigators will evaluate will be the number of mature eggs retrieved.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Undergoing IVF * Must meet POSEIDON criteria based on clinic evaluation * Female partner: Antral follicle count of 2 or more and age \<45 at time of stimulation start * Male partner/sperm source: Cannot be azoospermic * Planning freeze-all cycle (regardless of blastocyst or cleavage stage culture) or fresh transfer if randomized to short Clomid group * Planning 36-hour trigger window Exclusion Criteria: * Normal ovarian reserve or good response * Allergy or adverse reaction to Clomid * Minimal stimulation protocols * History of prior premature ovulation
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What it tests

  • Clomiphene Citrate
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Where

1 site
HRC Fertility
Pasadena, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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