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Role of Pavlovian Mechanisms for Control Over Substance Use

Recruitingn/aAges 18 Years - 65 YearsAllTechnische Universität Dresden
NCT06701487 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

During the first funding period (1st FP), the investigators developed a novel full Pavlovian-to-instrumental transfer (PIT) task that allows assessing both, general and specific PIT to investigate whether specific PIT differs between alcohol use disorder (AUD) and control subjects. Preliminary analyses of the full transfer task indicate that AUD participants exhibit a stronger specific PIT effect compared to controls. Based on these findings, the investigators want to compare specific and general PIT effects in patients with moderate to severe substance use disorders (alcohol, cannabis, methamphetamine, amphetamine and cocaine) to healthy controls on the behavioral and neural level (fMRI).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Men and women between 18-65 years of age, * AUD, and/or SUD subjects only: meet 4 or more criteria for DSM-5 alcohol-related and/or substance-related (cannabis, amphetamine, methamphetamine or cocaine disorder (not requiring withdrawal as assessed by an independent psychiatrist), * Currently using alcohol without a desire for abstinence * Ability to consent to the study and complete the questionnaires. * Sufficient language(German) and motor skills for using PC * existing health insurance Exclusion Criteria: * Lifetime diagnosis of DSM-5 bipolar disorder or schizophrenia or schizophrenia spectrum disorder (if induced by drugs, it should happen more than a month ago) * Current threshold DSM-5 diagnosis of major depressive disorder, or presence of suicidal intention * High risk (≤ 26) ASSIST scores in other substances other than alcohol, amphetamine, methamphetamine, cannabis, cocaine, tobacco * History of traumatic brain injury or severe neurological disease (such as Dementia, Parkinson's disease, multiple sclerosis, Epilepsy, Meningitis, Stroke) * Pregnancy or breastfeeding, * Ingestion of medications known to interact with the dopamine system in the 10-day period prior to study participation or less than 4 half-lives after last ingestion (rapid urine test); A detailed list of permitted medication can be added upon request * MR contraindications (e.g., pacemakers, metallic or electronic implants, metallic splinters, surgical staples) * Color vision deficiency * sensorineural hearing loss of 30 dB or greater, * Tinnitus and * Acute alcohol, substance (cannabis, or methamphetamine, amphetamine, cocaine) intoxication at assessement day verified by breath alcohol tests and drug intoxication verified by rapid urine test.
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What it tests

  • fMRI imaging (BOLD)
  • sMRI (structure)
  • Pavlovian-to-instrumental transfer (PIT) paradigm
  • Basic psychological assessment (interview)
  • Basic psychological assessment (questionnaires)
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Where

1 site
Department of Psychiatry and Psychotherapy, Technische Universität Dresden
Dresden, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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