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Effects of a Healthy Nordic Diet on Atherosclerosis in Patients with Coronary Heart Disease

RecruitingNAAges 50 Years - 80 YearsAllUppsala University
NCT06701968 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Diet can play a key role in atherosclerosis and coronary heart disease (CHD), but little interventional data exists, and the mediators of possible anti-atherosclerotic effects of diet are unclear. The investigators will investigate if a healthy Nordic diet (HND) reduces plaque volume, coronary artery calcification (CAC), and plaque inflammation (FAI) in CHD, and examine if changes in gut microbiota may be linked to plaque progression over time. The investigators will also explore if the diet response can be predicted by the metabolic phenotype. In total 150 CHD patients is randomized to a HND rich in unsaturated fat and fibre from plants, or to a "usual care diet" for 18 months. Plaque volume and composition is assessed by CT, and fecal microbiota composition is determined by deep metagenome shotgun sequencing. CHD and metabolic risk factors, liver fat, muscle fat and biomarkers of diet

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📋 Eligibility rules (as published)
Inclusion Criteria: * Men and women * Diagnosis with MI from 2 weeks after diagnosis and with maximum 6 months after diagnosis * Diagnosis with CCS (e.g. stable angina pectoris) * Ages 50 to 80 years * BMI 25-40. Exclusion Criteria: * Severe heart failure (NYHA classes III, IV) * Alcohol intake \>20g/day * Unwillingness to follow a new prescribed diet for 18 months * Other diseases implying a short estimated life expectancy (e.g. severe malignant or kidney or liver disease, as judged by consenting physician).
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What it tests

  • Healthy Nordic Diet
  • Usual Care
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Where

1 site
Cardiology clinic, Uppsala university hospital
Uppsala, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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