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โ† Trials
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Precision Diagnosis and Care for Families With Pulmonary Fibrosis in Ireland

Recruitingn/aAges 18 Years - 85 YearsAllRoyal College of Surgeons, Ireland
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In plain words

What the trial is, and whether it could suit you

This study aims to improve the understanding of how genes and the environment can influence and cause pulmonary fibrosis. By identifying the presence of genes and other factors that can put people at risk of developing pulmonary fibrosis, the influence these factors have on the progression of the disease can be studied. Interstitial lung disease (ILD) is the medical term given to a group of lung diseases affecting the same part of the lung, the interstitium, each with similar symptoms. In some of these diseases, inflammation leads to lung scarring, known as fibrosis. Idiopathic Pulmonary Fibrosis (IPF) is one of these diseases; it has a particular pattern on computed tomography (CT) scans. IPF is 'idiopathic' as it is not yet fully understood why it happens. It has a poor prognosis. The average survival time is three to five years after diagnosis. While new antifibrotic drugs offer hope

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Able and willing to give written informed consent. * An MDT diagnosis of fibrotic ILD which fall into one of the following three catagories; 1. Have a multidisciplinary team (MDT) diagnosis of a fibrotic interstitial lung disease, reporting one or more relatives with a fibrotic form of ILD 2. Have a MDT diagnosis of IPF in accordance with consensus criteria, ATS, ERS, JRS, ALAT guidelines without a family history of pulmonary fibrosis. 3. Meet the American College of Rheumatology/European League Against Rheumatism criteria for rheumatoid arthritis, scleroderma, Sjogren's syndrome, idiopathic inflammatory myopathy and systemic lupus erythematosus. Exclusion Criteria: * Currently participating in an interventional clinic trial. * Change in clinical phenotype from initial radiological diagnosis to screening. * Acute or chronic hypersensitivity pneumonitis with consensus criteria (appropriate exposure history, radiological features ยฑ avian and fungal precipitins). * Asbestosis (appropriate occupational history and radiological evidence of asbestos exposure) * Life expectancy for any disease, including ILD \<12 months (investigator assessment) * Major extrapulmonary physiological restriction (e.g. chest wall abnormality, large pleural effusion)
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What it tests

  • Six minute walk test (6MWT)
  • Computer-tomography of the thorax (CT Thorax)
  • Quality of life questionnaires.
  • Genetic Testing
  • Spirometry
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Where

1 site
Beaumont Hospital
Dublin, Ireland
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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