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PEEP FOR LUNG RECRUITMENT IN PRETERM INFANTS-EIT STUDY

RecruitingNAAges 22 Weeks - 32 WeeksAllSouth Tees Hospitals NHS Foundation Trust
NCT06705257 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Babies born early (under 32 weeks) are at risk of developing lung problems after birth. A major reason for this is that the lungs are not fully developed. Lungs of preterm babies will often collapse in between breathing due to lung immaturity. Applying gentle pressure, using nasal device through their nostril or through the breathing tube helps to prevent this lung collapse. This would help in air-oxygen going to lungs and also makes the babies breathing more comfortable. This gentle pressure is medically called as PEEP/CPAP and could be delivered by breathing machine (ventilator) and CPAP machine, collectively called as "continuous distending pressure (CDP)". Those babies breathing on their own and receiving inadequate CDP would need more breathing support by placing them on breathing machine (ventilator). The longer the baby receives breathing machine support, higher chance of lung in

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📋 Eligibility rules (as published)
Inclusion criteria 1. Gestational age \<32 weeks based on mother's last menstrual period or first trimester ultrasound dating. 2. Receiving either CPAP or mechanical ventilation respiratory support. 3. Informed written consent from one of the parents. 4. Within the first two weeks of life. Investigators pragmatically chose this period, as there could be considerable lung injury after the first two weeks of life, making it difficult to test our hypothesis. Also, this time period would allow parents to settle down with their stressful preterm delivery and investigators could approach anytime within the first two weeks of life. Exclusion criteria 1. Major congenital malformations including congenital lung disease and congenital heart disease as ascertained by the medical team. 2. Infants diagnosed with pneumothorax i. 3. Receiving high frequency mechanical ventilation. 4. Infants with concerns of skin integrity.
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What it tests

  • Studying the effects of varying levels of PEEP using Electrical impedance tomography
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Where

1 site
South Tees NHS Trust
Middlesbrough, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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