Mediterranean Diet Effects on Parkinson's Disease

Inclusion Criteria: 1. PD diagnosis according to international guidelines; 2. Age between 40 and 85 years; 3. Naive to medication or with a stable dosage of anti-Parkinson's therapy for at least two weeks; 4. Hoehn \& Yahr stage ≤3; 5. Normal independent feeding; 6. Ability to complete informed consent; 7. Willingness to maintain the usual diet in the period between T0 and T1; 8. Willingness to maintain the usual diet if randomized to the control group in the T1-T2 period; 9. Willingness to make changes in their diet to follow a Mediterranean diet if randomized to the intervention group in the T1-T2 period; 10. Willingness to fill out questionnaires; 11. Willingness to provide blood samples during the study collection periods; 12. Willingness to provide stool samples during the study collection periods; 13. Willingness to fast (without food or drink except water, tea or coffee) at least 12 hours before each sample collection; 14. Willingness to discontinue taking supplements, probiotics, herbal or high- dose vitamins or minerals that could impact inflammation during the period between T0 and T1 and for the duration of the study protocol; 15. No medical and/or social conditions that could interfere with participation in a six-month interventional study. Exclusion Criteria: 1. Atypical or secondary parkinsonism; 2. Underweight (\<18.5); 3. Obesity (BMI\>30); 4. Pregnancy or suspected pregnancy; 5. Normal assisted nutrition; 6. Enteral nutrition; 7. Chronic autoimmune diseases; 8. Chronic use of immunosuppressive drugs in the past year; 9. Chronic use of cytotoxic cancer drugs in the past year; 10. Major abdominal surgeries; 11. Concurrent participation in other interventional studies; 12. Intentional change in diet after PD diagnosis.