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โ† Trials
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Targeting Vascular INflammation in Patients With Community-Acquired Pneumonia

RecruitingPhase 3Ages 18 Years - anyAllOttawa Heart Institute Research Corporation
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn if icosapent ethyl (Vascepa) works to lessen the amount of inflammation in adults diagnosed with Community-Acquired Pneumonia (CAP). The main question it aims to answer is: What is the effect of taking Vascepa on inflammation in the arteries in patients with CAP? Researchers will compare the drug Vascepa to a placebo (a look-alike submstance that contains no drug) to see if Vascepa works to reduce inflammation in patients with CAP. Participants wil: * take Vacscepa or a placebo twice a day for 6 months * Visit the clinic 3 times (baseline, 30 days, and 6 months) for checkups and tests

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: Patients who have: 1. Hospitalization with CAP (defined as pulmonary infiltration using chest imaging, in addition to other clinical symptoms including fever, cough, and sputum) 2. age \> 18 years; 3. given informed consent. Exclusion Criteria: Patients who have: 1. history of cancer within the last 3 years (other than a successfully treated cutaneous squamous cell or basal cell carcinoma or localized carcinoma in situ of the cervix). 2. active inflammatory conditions (e.g. rheumatoid arthritis, chronic inflammatory bowel disease, SLE, systemic anti-inflammatory therapy (e.g. prednisone, methotrexate)); 3. pregnancy (all women of child bearing potential will have a negative BHCG test; 4. breastfeeding; 5. Women of childbearing potential who refuse to use two forms of contraception (this includes at least one form of highly effective and one effective method of contraception) throughout the study OR men capable of fathering a child who refuse to use contraception. 6. Allergies to icosapent ethyl 7. allergies to fish or shellfish 8. glomerular filtration rate (GFR) \<50 ml/min/1.72m2 (excluded from CTA portion) 9. unable to give informed consent; Exclusion for CTA portion of the protocol: Patients with dye allergy will not undergo CTA but will have PET/CT
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What it tests

  • Icosapent Ethyl 1000 MG Oral Capsule [Vascepa]
  • Placebo
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Where

1 site
University of Ottawa Heart Institute
Ottawa, Canada
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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