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Effect of Dexmedetomidine on Hemodynamic Response to Endotracheal Intubation in Hypertensive Patients

RecruitingPhase 1, Phase 2Ages 60 Years - anyAllLiaquat National Hospital & Medical College
NCT06712186 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Dexmedetomidine, an alpha-2 adrenergic agonist, has been shown to provide several benefits during endotracheal intubation: 1. \_Reduced anxiety and stress\_: Dexmedetomidine's anxiolytic and sedative effects help reduce anxiety and stress associated with endotracheal intubation. 2. \_Improved intubating conditions\_: Dexmedetomidine can improve intubating conditions by reducing the incidence of coughing, bucking, and laryngospasm. 3. \_Decreased hemodynamic responses\_: Dexmedetomidine can attenuate the hemodynamic responses to intubation, including tachycardia, hypertension, and increased cardiac output. 4. \_Increased ease of intubation\_: Dexmedetomidine can facilitate smoother and easier intubation by reducing the need for additional anesthetics or muscle relaxants. The physiological responses to dexmedetomidine during intubation include: 1. \_Decreased heart rate\_: Dexmedetomidi

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📋 Eligibility rules (as published)
Inclusion Criteria: * ASA Grade II * Age \> 60 years * Elective surgical procedures under GA. * All patients with a diagnosis of hypertension for 6 months or more and undergoing treatment with antihypertensive medications. Exclusion Criteria: * Patient refusal * ASA Grade III and IV * Severely Hypovolemic state * Emergency surgeries * Body weight more than 20% of ideal body weight. * Patients with known or unanticipated difficult intubation and those requiring more than 15 sec or two attempts at laryngoscopy * Allergic to dexmedetomidine * Non complaint hypertensive patients * Patients with uncontrolled hypertension.
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What it tests

  • Dexmedetomidine Group / Group D
  • Normal Saline (Placebo)
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Where

1 site
Liaquat National Hospital and Medical College
Karachi, Pakistan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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