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Extracellular Vesicles in Fibrin Gel for Cartilage Repair

Recruitingn/aAges 18 Years - anyAllI.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
NCT06713902 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This project aims to produce and study in vitro/ex vivo a platelet rich plasma (PRP)-derived fibrin gel loaded with mesenchymal stromal cells (MSC)-extracellular vesicles (EVs), to combine the positive results on cartilage growth of PRP growth factors and the hyaline cartilage stimulating activity of MSC-EVs. Therefore, the project goal is to provide an advanced option for orthopedic patients with an innovative evolution of a gold standard procedure, making it easy to translate into daily clinical practice for physicians, healthcare professionals and patients.

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📋 Eligibility rules (as published)
Inclusion Criteria: * males and females ≥ 18 * patients undergoing plastic surgery procedures; * patients undergoing elective joint surgery with a diagnosis of knee or hip osteoarthritis (any Kellgren-Lawrence grade); * patients undergoing regenerative medicine treatments with PRP with a diagnosis of knee or hip osteoarthritis (any Kellgren-Lawrence grade; * signed Informed Consent for the study Exclusion Criteria: * Positive virological test (HIV, HCV, HBV, TPHA) * Pregnancy or breastfeeding by self-declaration * Other conditions that, at the discretion of the investigator or the physician
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What it tests

  • Not listed
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Where

1 site
I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Milan, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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