Phase 1 Study to Evaluate the Safety and Tolerability of Intravenously Administered PYC-003

Part A (SAD - Healthy Volunteers) Key Inclusion Criteria 1. Adult aged 18 to 60 years (inclusive) 2. At the discretion of the PI or designee, in good general health, with no significant medical history, and have no clinically significant abnormalities on physical examination at Screening 3. BMI ≥ 18.0 and ≤ 32.0 kg/m2 and weight ≥ 50 kg. 4. Non-smoker and must not have used any tobacco or nicotine products within 2 months prior to Screening. 5. Clinical laboratory values within normal range or deemed not clinically significant by the PI 6. eGFR ≥ 80 mL/min/1.73 m2 via the Chronic Kidney Disease Epidemiology Collaboration (CKD EPI) 2021 calculation 7. Woman of childbearing potential (WOBCP) must agree to use an acceptable, highly effective, double barrier method of contraception from the start of Screening until study completion. 8. Males must be surgically sterile (vasectomized for at least 6 months prior to first IP administration) or, if engaged in sexual relations with a WOCBP, must agree to use an acceptable, highly effective, double barrier method of contraception from the start of Screening until study completion. 9. Females must agree not to donate ova from the first administration of IP until 30 days following study completion. 10. Males must agree not donate sperm from the first administration of IP until 90 days following study completion. 11. Able and willing to attend the necessary visits to the study site. 12. Able and willing to adhere to caffeine, alcohol, and nicotine-containing product restrictions 13. Able and willing to provide written informed consent after the nature of the study has been explained and prior to the commencement of any study procedures. Part A (SAD - Healthy Volunteers) Key Exclusion Criteria 1. Females who are pregnant, breastfeeding, or plan to become pregnant during the course of the study. 2. Underlying physical or psychological medical condition that, in the opinion of the PI or designee, would make the participant unlikely to comply with the protocol or complete the study per protocol. 3. Has only 1 kidney or has received a kidney transplant. 4. Blood donation or had significant blood loss (\> 500 mL) within 30 days prior to the first administration of IP. 5. Plasma donation within 7 days prior to the first administration of IP. 6. Fever (body temperature \> 38°C) or symptomatic viral or bacterial infection within 2 weeks prior to first administration of IP. 7. Infections requiring parenteral antibiotics within 6 months prior to Screening. 8. Positive test for hepatitis C antibody (HCV), hepatitis B surface antigen (HBsAg), HIV antibody. 9. History of life-threatening infection (e.g., meningitis). 10. Vaccination with a live vaccine within 4 weeks prior to the first administration of IP. 11. Poor venous access. 12. History of severe allergic or anaphylactic reactions, or sensitivity to the IP or its constituents. 13. History of malignancy, except for non-melanoma skin cancer excised more than 1 year prior to Screening and cervical intraepithelial neoplasia that has been successfully cured more than 2 years prior to Screening. 14. Abnormal electrocardiogram (ECG) findings at Screening, Day -3 to Day -1, or predose that are considered by the PI or designee to be clinically significant. 15. History or presence of a condition associated with significant immunosuppression. 16. Exposure to any drugs that cause significant immunosuppression (including experimental therapies as part of a clinical study) within 4 months or 5 half-lives (whichever is longer), prior to Screening. 17. ALP, AST, and ALT \> 1.5 × ULN at Screening or Day -3 to Day -1. 18. History of borderline to low blood magnesium and potassium levels and/or Screening or Day -3 to Day -1 blood magnesium level \< 0.7 mmol/L and potassium levels \< 3.5 mmol/L. 19. Active infection of the urinary tract (ie, kidney, bladder). 20. Positive toxicology screening panel (urine test including qualitative identification of amphetamines, barbiturates, benzodiazepines, cocaine, methamphetamine, methadone, opiates, phencyclidine, tetrahydrocannabinol \[THC\], tricyclic antidepressants), or alcohol breath test. 21. History of substance abuse or dependency or history of recreational IV drug use over the last 5 years (by self-declaration). 22. Regular alcohol consumption defined as \> 14 standard drinks per week for females and \> 21 standard drinks for males (where 1 standard drink = 375 mL of mid-strength beer \[3.5% alcohol/volume\], 100 mL wine \[13.5% alcohol/volume\] or 30 mL of spirits \[40% alcohol/volume\]) or \> 4 standard drinks on any single day. 23. Unwilling to abstain from alcohol for 48 hours prior to admission to the study site and for 48 hours prior to any follow-up visits. 24. Use of any investigational medical device or investigational drug within 30 days or 5 half-lives of the investigational drug (whichever is longer) prior to the first administration of IP. 25. Use of (or anticipated use of) the following: 1. Any prescription drugs (other than hormonal contraception; oral contraceptive pills, long-acting implantable hormones, injectable hormones, a vaginal ring, or an intrauterine device \[IUD\]) within 14 days prior to the first administration of IP and during the course of the study without prior approval of the PI and MM. 2. Any over-the-counter medication, herbal remedies, supplements or vitamins within 7 days prior to the first administration of IP and during the course of the study without prior approval of the PI and MM. Note: Paracetamol (i.e., up to 2000 mg per day) may be used for minor ailments during the study, at the discretion of the PI, without prior consultation with the MM. 26. Unwilling to refrain from strenuous exercise (including weightlifting) for 48 hours prior to admission to the study site and for 48 hours prior to any follow-up visits. 27. Anything that the PI considers would jeopardize the safety of the participant, prevent complete participation i