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Cell Free DNA Profiling As a Tool to Monitor Clinically-Relevant Events in Allogeneic Hematopoietic Stem Cell Transplantation

Recruitingn/aAges 18 Years - anyAllUniversity of Turin, Italy
NCT06715046 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Allogeneic hematopoietic stem cell transplantation (HSCT) is a life-saving treatment for people with severe blood-related diseases. However, it comes with serious risks, including a condition called graft-versus-host disease (GVHD), where the transplanted cells attack the patient's body. GVHD can occur in about 50% of patients acutely and 35% in a chronic form, potentially affecting organs like the skin, liver, and gastrointestinal system. Currently, doctors diagnose GVHD based on symptoms, as there are no easy tests available. Infections can also be a problem after HSCT, as dormant viruses may reactivate. These infections are monitored using specialized tests. Additionally, doctors use advanced methods, like analyzing minimal residual disease (MRD) and chimerism, to check for the risk of the original disease coming back. MRD is tracked by looking for specific genetic markers of the dis

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient must be affected by an hematological malignancy requiring hematopoietic stem cell transplantation (HSCT). Exclusion Criteria: * Patients can not be 17 years old or yunger
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What it tests

  • Sample collation for cfDNA methylation analysis
  • Sample collection for EV phenotype analysis
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Where

2 sites
Unità di Ematologia e Trapianto di Midollo Osseo e Oncoematologia of the San Raffaele Hospital in Milan
Milan, Italy
SS Trapianto allogenico e terapie cellulari, SC Ematologia U of the Città della Salute e della Scienza Hospital
Turin, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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