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Intravenous Versus Oral Treatment of the Main Acute Infections

RecruitingNAAges 18 Years - anyAllUniversity of Southern Denmark
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In plain words

What the trial is, and whether it could suit you

Patients admitted to the hospital with acute infections are often treated with intravenous (IV) antibiotics. Around 70% of these infections fall into three categories: respiratory tract infections, urinary tract infections, and cellulitis. A Danish study found that 76% of patients admitted with suspected community-acquired pneumonia and treated with antibiotics received them intravenously. Based on an extrapolated estimate from an unpublished local survey, approximately 50,000 patients in Denmark are admitted each year for infections and treated with IV antibiotics. The average hospital stay for these patients is 5.9 days, resulting in a total of 295,000 hospital days annually, accounting for about 7% of total hospital admissions in Denmark. This represents an annual cost of 2.3 billion DKK. While some patients need hospitalization due to their overall health or other serious conditions,

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📋 Eligibility rules (as published)
Inclusion Criteria: * Suspected respiratory tract infection, urinary tract infection, or cellulitis by the attending physician * Planned or initiated intravenous antibiotic treatment Exclusion Criteria: * if received more than two doses of intravenous antibiotics; * systolic blood pressure \<90 mmHg; * nausea and/or vomiting in more than one short-term instance during the last 2 days; * suspected significantly reduced gastrointestinal absorption; * confirmed plasma-lactate \> 2; * pregnant or nursing; * unable to give informed consent; * severe immunodeficiency; * urgent vital treatment needed.
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What it tests

  • Oral treatment
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Where

7 sites
Sygehus Sønderjylland
Aabenraa, Denmark
Bispebjerg and Frederiksberg Hospital
Copenhagen, Denmark
Nordsjællands Hospital
Copenhagen, Denmark
Esbjerg and Grindsted Sygehus
Esbjerg, Denmark
Herlev and Gentofte Hospital
Herlev, Denmark
Amager and Hvidovre Hospital
Hvidovre, Denmark
Sygehus Lillebælt
Kolding, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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