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Effects of Exogenous Ketones on Acute Changes and Recovery of the Heart Muscle After Intense Exercise.

RecruitingPhase 4Ages 18 Years - 50 YearsAllJessa Hospital
NCT06715748 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

It is well known that scar tissue on the heart muscle can cause (life-threatening) arrhythmias. However, the exact cause of this scar tissue is not entirely clear. It is possible that prolonged and intense exercise is associated with (limited) inflammation of the heart muscle, carrying the risk of scar tissue development. The aim of this project is to evaluate the impact of prolonged and intense exercise on the heart. Participants will be asked to cycle for a total of 3 hours, of which 2 hours will be at an intense pace. Approximately 30 recreational cyclists will be invited to participate in this research project. Specifically, the investigators want to examine whether prolonged and intense exercise is associated with inflammation of the heart muscle and whether it affects heart function recovery. The research project will take place in a laboratory setting, where heart rate, blood pre

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📋 Eligibility rules (as published)
Inclusion Criteria: * healthy recreational male and female cyclists between 18 and 50 years old, who have signed an informed consent form. * Participants will be included if they achieve a VO2-max/kg value above P90, corrected for age and sex, based on the reference value by E. Van der Steeg et al. Exclusion Criteria: * Cardiovascular, metabolic, or respiratory diseases * Participants with cardiovascular risk factors * Contraindications for maximum exercise * Contraindications for MRI.
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What it tests

  • Ketone Monoester (KE)
  • Placebo
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Where

1 site
Jessa Hospital
Hasselt, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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