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A Study to Investigate ANS03 in Participants With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1Ages 18 Years - anyAllAvistone Biotechnology Co., Ltd.
NCT06716138 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a first-in-human Phase I, multi-center, open-label study of ANS03 in patients with advanced solid tumors. The study evaluates the safety, tolerability, preliminary efficay, pharmacokinetics, anti-tumor activity of ANS03 as monotherapy.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years * Eastern Cooperative Oncology Group (ECOG) Performance Status: 0-2 * Life expectancy ≥ 12 weeks * Measurable disease per RECIST v1.1 * Adequate organ and marrow function as defined in the protocol * With documentation of ROS1 or NTRK alteration Exclusion Criteria: * Active infection including tuberculosis and HBV, HCV or HIV * Known active or untreated CNS metastases * Participants with carcinomatous meningitis or meningeal metastases, or spinal cord compression * Participants with serious cardiovascular or cerebrovascular diseases
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What it tests

  • ANS03
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Where

5 sites
Memorial Sloan Kettering Cancer Center
New York, United States
Research Site
Fuzhou, China
Research Site
Guangzhou, China
Research Site
Shanghai, China
Research Site
Chengdu, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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