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Biodegradable Stents in Liver Transplant RecipIents for Treatment of Biliary Anastomotic Strictures

RecruitingNAAges 18 Years - anyAllInstitute for Clinical and Experimental Medicine
NCT06716541 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Biliary complications after liver transplantation (LT) remain common and are associated with higher morbidity in liver transplant recipients and liver graft failure. Anastomotic biliary strictures are the most common biliary strictures after LT. Today, the gold standard for treatment remains endoscopic retrograde cholangiopancreatography (ERCP) with either multiple plastic stenting (MPS) or fully covered metal stents. These methods have disadvantages such as the need for repeated ERCP procedures, high costs or the risk of migration. Biodegradable stents (BDS) are a novel type of stents made from various synthetic polymers or their copolymers, which are now being used in a variety of medical fields, including the pancreatobiliary tract.The use of biodegradable stents has shown good potential in the treatment of benign biliary strictures. However, overall data on their endoscopic use in l

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥18 years * Liver transplant recipients * Duct-to-duct biliary anastomosis * Anastomotic biliary stricture (cholestasis unexplained by other causes and/or liver biopsy showing altered biliary drainage and/or anastomotic stricture on MRCP) * Signed informed consent Exclusion Criteria: * Hepaticojejunoanastomosis * Physical and/or psychological inability to understand the aims of the research and to adequately cooperate * Pregnancy
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What it tests

  • ERCP implantation of a biodegradable stent
  • ERCP implantation of plastic stents
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Where

1 site
Institute for Clinical and Experimental Medicine, Department of Gastroenterology and Hepatology
Prague, Czechia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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