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Remimazolam Besylate in Sedation of Postcardioperative Patients

RecruitingNAAges 18 Years - anyAllFirst Affiliated Hospital of Zhejiang University
NCT06716840 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Intensive care medicine is vital in managing patients after cardiac surgery with endotracheal intubation，in order to provide extensive monitoring to assure clinical stabilization. During this time of recovery, sedation is frequently employed. However, prolonged sedation risks negative sequelae.At present,propofol, benzodiazepines, and dexmedetomidine are typical drugs used for sedation of patients in intensive care unit.Each has its own advantages and disadvantages.The investigators try to find near-ideal agents for sedation,characterized by good sedative effect,minimal adverse effects and rapid awakening facilitating earlier extubation.Remimazolam appeared to be an effective and safe sedative for short term sedation. Study participants were predicated on age (\> 18 years), admission following cardiac surgery, still mechanical ventilation within 48 hours,and prior informed consent.Partic

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. age ≥ 18 years ; 2. admitted to the intensive care unit after cardiac surgery with techanical ventilation； 3. expected to extubation within 48hours ； 4. participant has given informed consent Exclusion Criteria: 1. pregnant or lactating women 2. known or suspected hypersensitivity to the study drug 3. history of impaired consciousness or psychiatric illness 4. severe bradycardia with a heart rate of \< 50 beats per minute 5. systolic blood pressure \< 90 mmHg with fluid resuscitation and vasopressor maintenance 6. atrioventricular block（II or III degree）, Left ventricular ejection fraction(LVEF) \<30% 7. participated in other clinical studies within 3 months
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What it tests

  • Remimazolam
  • Propofol
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Where

1 site
First afflilated hospital of zhejiang university school of medicine
Hangzhou, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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