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Optimising HFO&VTV in Newborn Infants

RecruitingNAAges 22 Weeks - 1 YearAllKing's College Hospital NHS Trust
NCT06719284 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Mechanical ventilation (MV) is life saving for infants requiring respiratory support in the newborn period but its use has been associated with complications. High frequency oscillation (HFO) is a type of MV that delivers small volumes of gas across the lungs at fast frequencies. HFO is a lung protective strategy but it has also been linked to brain injury due to low carbon dioxide tensions. High-frequency oscillation with volume-targeted ventilation (HFO\&VTV) is a new mode of HFO in which the clinician sets a target volume of gas to be delivered to the lungs at fast rates to decrease the lung injury related to the ventilator. Further, HFO\&VTV achieves better control of carbon dioxide levels and may therefore protect against brain injury. Currently, there are no written guidelines about the use of HFO\&VTV. This study aim to determine the safety profile of HFO\&VTV compared to HFO by c

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📋 Eligibility rules (as published)
Inclusion Criteria: -Newborn infants of any gestation receiving high frequency oscillatory ventilation Exclusion Criteria: * Infants with known intracerebral pathology (stroke, hydrocephalus, intracerebral hemorrhage, severe hypoxic ischemic encephalopathy). * Infants with congenital cardiac abnormalities.
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What it tests

  • HFO&VTV at targeted tidal volumes of 1.5, 2.0 and 2.5 ml/kg in random order
  • HFOV at the settings applied prior to the study
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Where

1 site
King's College Hospital
London, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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