HD-tDCS in Amyotrophic Lateral Sclerosis: A Multicenter Randomized Controlled Trial

Inclusion Criteria: * Both sexes; diagnosis of ALS according to the revised El Escorial criteria; * Age between 18 and 80 years; * Forced Vital Capacity greater than 50% of predicted; * Sniff nasal inspiratory pressure greater than 40 cmH2O; * A telephone number to contact the care team and who signed the study consent form. Exclusion Criteria: * Subjects who are unable to understand or perform any of the study procedures; * Subjects who do not agree to participate or voluntarily request withdrawal from the study at any time; * Subjects with cardiac, respiratory, or musculoskeletal comorbidities; * Subjects using invasive mechanical ventilation; * Subjects with a tracheostomy; * Subjects with a pacemaker; * Subjects with metallic brain implants or other electronic implants; * Subjects with a cochlear implant; * Subjects with epileptic activity or a history of epilepsy, or a family history of epilepsy; * Subjects with a history of stroke or tumor; * Subjects prone to severe hemodynamic fluctuations, acute infectious processes, and/or inflammatory conditions; * Pregnant women at the time of recruitment; * Subjects who are unable to complete the intervention protocol.