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School-based Program for the Prevention of Rheumatic Heart Disease in Endemic Regions

RecruitingNAAges 5 Years - 16 YearsAllThomas Pilgrim
NCT06720272 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The overall objective of the PREVENT trial is to evaluate the effectiveness of an integrated, school-based program for the prevention of rheumatic heart disease (RHD) in regions with an endemic pattern of RHD. We conduct a stepped wedge cluster randomized trial in randomly selected schools in Nepal and Zambia. The intervention will be delivered at the level of the school and consists in the introduction of a dedicated school-nurse program providing health care through education about RHD, assessment, intervention, and follow-up of GABHS pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with RHD.

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📋 Eligibility rules (as published)
Inclusion Criteria: \- Children aged 5-16 years Exclusion Criteria: * Children / primary caregivers not providing informed consent to participate * Children not attending one of the selected schools
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What it tests

  • School nurse program
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Where

2 sites
National Academy od Medical Sciences
Kathmandu, Nepal
Centre of Infectious Disease Research
Lusaka, Zambia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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