The Collagen Factors of Rapid Progression of Keratoconus in Children.

Inclusion Criteria: * ① Patients with keratoconus who visit the refractive clinic. 1. The height of the posterior corneal surface is greater than 16 microns under the Pentacam corneal topography. 2. ARTAve \< 424 microns, ARTMax \< 339 microns. 3. Clinical non-inflammatory or traumatic corneal thinning and corneal astigmatism. * Aged between 10 and 50 years old, no gender restrictions. * Agree to accept and complete follow-up examinations on time. ④ I and my guardian understand and agree to participate in this clinical trial and sign the informed consent form. Exclusion Criteria: * ① There is a history of contact lens wearing in the last four weeks. * poor fixation and can not cooperate with the examination. ③ History of eye trauma and surgery (including corneal collagen cross-linking surgery). * History of other related eye diseases: corneal disease, glaucoma, retinal choroid disease, etc.. ⑤ severe eye diseases affecting imaging such as dry eye, conjunctivitis and pterygium. ⑥ Any systemic disease affecting eye morphology and refractive interstitium.