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Assessment of Nebulized Tranexamic Acid in Functional Endoscopic Sinus Surgery Using Modena Bleeding Score

RecruitingEARLY Phase 1Ages 18 Years - 65 YearsAllAssiut University
NCT06725732 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of this study is to investigate the effect of preoperative administration of intravenous or nebulized tranexamic acid on surgical field, blood loss, anesthetic consumption and hemodynamics of patients undergoing FESS. Primary outcome Modena Bleeding Score (MBS) assessing surgical field Secondary outcome 1. Patient hemodynamics. 2. Anesthetic consumption, Extra doses of fentanyl and propofol and sevoflurane\>2 3. Postoperative complications: including any adverse effects to TXA e.g.nausea, vomiting, any visual disturbances, fits, and any thrombotic manifestation.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Either sex 2. age 18-65 years 3. ASA I-II who are listed for elective functional endoscopic sinus surgery (FESS) under general anesthesia 4. normal accepted coagulation profile and hematocrit value ≥30 Exclusion Criteria: * • chronic renal failure * liver cirrhosis * bleeding disorders * current anticoagulant therapy * pregnancy or breastfeeding * impaired color vision * severe vascular ischemia * history of venous thrombosis, pulmonary embolism * long term treatment with acetylsalicylic acid or non-steroidal anti-inflammatory drugs not discontinued before surgery * hemoglobin (HB) concentration \<10 mg/dl \_allergy to TXA. * BMI \> 35 kg/ m2
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What it tests

  • Tranexamic Acid (TXA)
  • Tranexamic Acid
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Where

1 site
Main building, Assiut University Hospitals
Asyut, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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