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Polymer Induced Liquid Precursor (PILP) in Adults in With Dentin Caries

RecruitingNAAges 18 Years - 64 YearsAllUniversity of California, San Francisco
NCT06727110 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn if polymer-induced liquid precursor (PILP) can be used safely to treat dentin caries (cavities) in adults. The main question it aims to answer is: Is PILP (conditioner or liner) safe in adult teeth with dental caries? Researchers will compare PILP to a placebo (a look-alike substance that contains no drug) to see if PILP safely treats cavities in teeth. Participants will: 1) Have PILP or placebo applied to their tooth prior to the placement of a filling in the tooth, 2) Complete two telephone calls within three months of filling placement and 3) Visit the clinic at three months and six months after the placement of the filling.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Stated willingness to comply with all study procedures and availability for the duration of the study 2. Male or female, aged 18 to sixty-four 3. In good general health as evidenced by medical history (ASA 1 or 2) 4. With at least one posterior tooth with caries to dentin 1. The tooth must have a pulpal diagnosis of pulpal health (no irreversible pulpitis or periapical radiolucency) 2. The tooth should have no existing restorations 3. The caries should be a Class I or class V single surface lesion 4. The tooth should be planned for restoration with intra-coronal restoration (composite or RMGI restoration) 5. The tooth should be deemed as needing a restoration based on ICDAS (International Caries Detection and Assessment System) Exclusion Criteria: Known allergic reactions to components of the study device
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What it tests

  • PILP Cement
  • PILP Conditioner
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Where

1 site
University of California San Francisco, School of Dentistry
San Francisco, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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