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Transcranial Pulse Stimulation. a Potential Treatment for Early Dementia

RecruitingNAAges 18 Years - anyAllFrancesca Pistoia
NCT06730438 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Alzheimer's Disease (AD) is characterized by the absence of treatments to slow, stop, or reverse its course, with patients finally losing cognitive functions, skills and independence. It is a chronic degenerative disease with high social and medical burden worldwide: AD ranked third among neurological disorders in terms of disability-adjusted life years (DALY) rates. The primary aim of the research protocol is to improve care for patients with AD, by implementing, with an innovative method, the currently available repertoire of neuromodulation techniques. For this aim, we will investigate whether Transcranial Pulse Stimulation (TPS) may induce cognitive improvement in patients with an early stage of dementia.

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📋 Eligibility rules (as published)
Inclusion Criteria: * age\>18 years * diagnosis of early dementia according to current international guidelines * disease duration of at least 12 months * consent to participate in the study. Exclusion Criteria: * medical instability interfering with standard neurological assessment * any contraindication to preliminary MRI for MR-based real-time neuronavigation * comorbidities which may interfere with cognitive status * any contraindication to Transcranial Pulse Stimulation.
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What it tests

  • Transcranial Pulse Stimulation
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Where

2 sites
San Salvatore Hospital
L’Aquila, Italy
San Salvatore Hospital
L’Aquila, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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