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Microbiota Transplantation in Solid Organ Transplantation

Recruitingn/aAges any - anyAllThe Second Hospital of Nanjing Medical University
NCT06730451 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Solid organ transplantation (SOT), an alternative therapy for end-stage diseases, offers increased longevity and better quantity of life. Posttransplant complications such as gastrointestinal symptoms, infection, and graft rejection increase risk with graft failure and death. However, the treatment of abovementioned complications remains unsatisfactory. Gut dysbiosis has been reported in patients with SOT, especially in patients with posttransplant complications. Recipients are more susceptible to gut dysbiosis as long-term use of immunosuppressants, antibiotics and corticosteroids. Restoring gut microbiome may be a promising therapy for posttransplant complications. Washed microbiota transplantation (WMT) is a newly improved methodology of fecal microbiota transplantation based on automatic facilities, washing process and a new delivery routine. In this study, investigators aimed to eva

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. solid organ transplantation recipients; 2. suffering from gastrointestinal symptoms (e.g. diarrhea, constipation, abdominal pian), infection (e.g. Clostridium difficile) post-transplantation and so on; 3. is willing to undergo WMT and provide written informed consent. Exclusion Criteria: 1. patients with history of gastrointestinal diseases or homologous pathogen infection pre-transplant; 2. pregnant or lactating females; 3. expected survival\<1 months; 4. unable to understand the purpose of the study, communicate effectively with investigators and comply with all study procedures; 5. follow up less than 1-month post-WMT; 6. other conditions judged by investigators not suitable for study participation.
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What it tests

  • Washed Microbiota Transplantation
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Where

1 site
The Second Affiliated Hospital of Nanjing Medical University
Nanjing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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