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Non-steroidal Anti-inflammatory Drugs in Pleurodesis

RecruitingPhase 2Ages 18 Years - anyAllCentre Hospitalier Universitaire, Amiens
NCT06731647 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended in a multimodal pain management to reduce pain intensity and to spare opioid use. However, there is a controversy in its use in pleurodesis surgery as it could block the process of pleurodesis in surgical pneumothorax. In addition, NSAIDs could increase the risk of pneumothorax recurrence. The investigators hypothesized that NSAIDs are safe during pleurodesis with a better pain management without increasing the risk of pneumothorax reccurence.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age≥18-year-old * pneumothorax with an indication of pleurodesis * with or without minimal lung resection * via thoracotomy or thoracoscopy Exclusion Criteria: * Minor patient * Pregnant, parturient or breast-feeding patient * Severe polytrauma (associated with the presence of a Vittel criterion) * Purulent pleurisy * Hemopneumothorax * Lactose hyper sensibility * Contraindications to NSAID * Contraindications to tramadol * Contraindications to paracetamol * Curative anticoagulation * Patients under guardians or deprived of their liberty * Patient refusal
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What it tests

  • pleurodesis procedures
  • KETOPROFEN(RP19583)
  • Placebo
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Where

1 site
Centre Hospitalier Universitaire d'Amiens
Amiens, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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