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The Impact of PEEP-guided Electrical Impedance Tomography on Oxygenation and Pulmonary Mechanics in Moderate-to-severe ARDS

RecruitingNAAges 18 Years - anyAllVietnam Military Medical University
NCT06733168 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Acute respiratory distress syndrome (ARDS) in its moderate to severe forms is associated with high mortality. Mechanical ventilation (MV) remains the cornerstone of ARDS management but carries a significant risk of ventilator-induced lung injury (VILI). Positive end-expiratory pressure (PEEP), a fundamental component of MV, is widely utilized in clinical practice; however, optimal PEEP selection for patients with moderate to severe ARDS remains a complex and unresolved challenge. Electrical impedance tomography (EIT), a bedside imaging modality that evaluates regional ventilation distribution, offers a means of individualizing PEEP settings in mechanically ventilated patients. By balancing the competing risks of alveolar overdistension and collapse, EIT facilitates precision in PEEP titration. This study compares the impact of EIT-guided PEEP selection versus the conventional low FiO2-PE

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years. * Intubated moderate and severe ARDS according to the New Global Definition (PaO2/FiO2 ≤200 mmHg). * Used continuous sedation with or without paralysis. Exclusion Criteria: * Presence of pneumothorax that is either undrained or newly occurred. * Unstable hemodynamics with a mean arterial pressure \< 60 mmHg and unresponsive to resuscitation measures, and/or heart rate \< 60 bpm. * Contraindications for EIT (pacemakers, automatic external defibrillators, cases of chest trauma or recent chest surgery limiting EIT belt application). * Pregnancy. * Severe neuromuscular disease.
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What it tests

  • electrical impedance tomography
  • Non-EIT
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Where

1 site
Intensive Care Center, Bach Mai Hospital
Hanoi, Vietnam
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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