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Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults

RecruitingNAAges 50 Years - anyAllUniversidade Federal do Rio de Janeiro
NCT06733714 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

BACKGROUND Cognitive decline in older adults, especially those who develop Mild Cognitive Impairment and Alzheimer's Disease, currently has limited options of pharmacological treatments, with modest efficacy. Digital Cognitive Training (DCT) and Transcranial Alternating Current Stimulation (tACS) are two promising tools for cognitive remediation in this population. In this exploratory study, we investigate feasibility, tolerability and preliminary effects of the association of both interventions in older adults with cognitive complaints. METHODS Older adults with cognitive complaints are being enrolled for this study, which comprises 5 daily sessions of 30 minutes of DCT using the BrainHQ platform while simultaneously receiving theta tACS (6Hz, 1.6mA) targeting the Left Dorsolateral Prefrontal Cortex.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Healthy subjects over 50 years old, with cognitive complaints Exclusion Criteria: * Estimated Intelligence Quotient \<80 * Dependence on psychoactive substances (DSM-V) * Severe psychiatric or neurological disorders * Uncorrected visual/hearing problems * History of syncope for an unexplained reason or seizure less than a year ago * Previous stroke * Use of anticoagulants * Intracranial metallic prosthesis or cardiac pacemaker * Any contraindication to performing tACS
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What it tests

  • Transcranial Alternating Current Stimulation
  • Digital Cognitive Training
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Where

1 site
Clínica da Memória - IPUB / UFRJ
Rio de Janeiro, Brazil
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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