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EXTEND ARDS-J Esophageal Pressure Study

Recruitingn/aAges 16 Years - anyAllSapporo Medical University
NCT06734988 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

Background: Acute respiratory distress syndrome (ARDS) patients require careful assessment before extubation to prevent failure, which is associated with poor outcomes. While current guidelines recommend weaning protocols, these are based on general respiratory failure studies rather than ARDS-specific data. Esophageal pressure (Pes) measurement provides direct assessment of inspiratory effort but is rarely utilized clinically. Objectives: This Japanese sub-study of EXTEND ARDS aims to evaluate whether: 1. ฮ”Pes measurements during spontaneous breathing trials (SBT) can predict SBT failure 2. ฮ”Pes measurements post-extubation can predict 48-hour extubation failure Methods: This prospective observational study will be conducted in Japanese ICUs. Esophageal pressure will be measured using standardized Nutrivent balloons (4mL volume) with Hamilton ventilators. Balloon placement in the low

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Adult mechanically ventilated patients (โ‰ฅ 16 years old) with esophageal pressure monitoring, expected to receive invasive mechanical ventilator for more than 48 hours 2. Patients who meet the diagnosis of ARDS at the start of invasive mechanical ventilation based on a new global definition of ARDS. Exclusion Criteria: 1. Patients who already had tracheostomy at the start of invasive mechanical ventilation 2. Patients who were transferred to participating hospital more than 2 days after the start of invasive mechanical ventilation 3. Patients with terminal conditions at the start of invasive mechanical ventilation 4. Patients who have expressed their refusal to have their clinical data used in research
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What it tests

  • Not listed
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Where

1 site
Sapporo Medical University
Sapporo, Japan
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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