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Multicenter ALS Imaging Study

Recruitingn/aAges 18 Years - anyAllUniversity of Minnesota
NCT06735014 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a multi-site study of ALS participants and healthy controls who will undergo brain and cervical spine MRIs and NfL blood testing at up-to 4 time points over the course of a year. The primary goal is to identify objective biomarkers of disease progression that are biologically relevant, linearly progressive, and sensitive to change.

Sign in to get the eligibility rules as simple questions to take to your doctor.

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📋 Eligibility rules (as published)
For participants with ALS: * \< 36 months since onset of symptoms * Definite, probable, lab-supported probable, or possible ALS by El Escorial criteria OR definite, probable, or possible ALS per Awaji-Shima criteria OR meets Gold Coast criteria * Forced vital capacity within the last 90 days ≥ 60% of the predicted value * Able to consent for themselves * Able to read and speak English * Clear of any contraindications for MRI Exclusion Criteria: * Individuals will be excluded if they have any condition that makes MRI unsafe or if they are unable to comply with instructions. * All participants will undergo a neurologic examination at enrollment. Control participants with clinically significant abnormal findings on neurological examination will be excluded from the study.
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What it tests

  • Magnetic Resonance Imaging
  • Plasma neurofilament light chain (NfL) quantification
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Where

3 sites
University of Florida
Gainesville, United States
Northwestern University
Evanston, United States
University of Minnesota
Minneapolis, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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