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Evaluation of the Efficacy of Permanent Course Combined Therapy With CYTOFLAVIN® Intravenous Solution and CYTOFLAVIN Tablets, at 2-3 Stages of Rehabilitation of Patients With Post Intensive Care Syndrome

Recruitingn/aAges 18 Years - anyAllPOLYSAN Scientific & Technological Pharmaceutical…
NCT06735898 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Post intensive care syndrome (PIC syndrome) is an important problem in modern intensive care strategy. Understanding the mechanisms of PIC syndrome helps prevent it in patients with respiratory, neuromuscular transmission, and cognitive impairments that require prolonged support of vital functions. Significant role in the formation and severity of PIC syndrome is played by the severity of the systemic inflammatory response, which is an individual reaction of the body, and this determines the degree of neurological and psychological deficits. Chronic diseases such as diabetes mellitus, especially in the context of metabolic syndrome, worsen the course of PIC syndrome and delays recovery. Early initiation of rehabilitation measures in the intensive care unit and subsequent expansion of the individual rehabilitation program contributes to the rapid and successful recovery of not only vital

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📋 Eligibility rules (as published)
Inclusion Criteria: * Men and women over 18 years of age and older; * Stay in the ITU and (or) intensive care unit for at least 3 days; * Diagnosed "post intensive care" syndrome (PIC syndrome) with moderate-to-severe severity \>3\<6 points * Diagnosed modalities "critical illness polyneuropathy, respiratory neuropathy, dysphagia" of the domain "Neuromuscular complications" of PIC syndrome at 2-3 stages of the rehabilitation route at any value of PICS severity index * Diagnosed modalities "decreased gravitational gradient, decreased exercise tolerance" in the domain "Vegetative-metabolic complications" at 2-3 stages of the rehabilitation route at any value of PICS severity index Exclusion Criteria: * Premorbid level of vital activity when assessed on the rehabilitation routing scale 4-5 points; * Hematocrit ≤30%; * Hemoglobin level ≤80 g/L; * Acute cardiac failure; * Acute respiratory failure; * Acute renal failure; * Acute liver cell failure; * Use of drugs from "metabolic agents" pharmacotherapeutic group at the time of inclusion in the study * Life expectancy of 6 months or less or presence of incurable diseases in decompensation stage
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What it tests

  • Not listed
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Where

1 site
Brain Institute Clinic
Yekaterinburg, Russia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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