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Speech and Language Interventions for Italian People With PPA

Recruitingn/aAges 40 Years - 85 YearsAllIstituti Clinici Scientifici Maugeri SpA
NCT06739967 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Primary progressive aphasia (PPA) is an umbrella term used to refer to several clinical variants that manifest as an insidious deterioration of speech/language skills, usually due to frontotemporal lobar degeneration and/or Alzheimer's disease. Consensus criteria have been proposed by an international community regarding the sub-classification of PPA into three variants: (1) semantic variant PPA, characterized by impaired confrontation naming and single-word comprehension; (2) logopenic variant PPA), characterised by word-finding difficulties and sentence repetition deficits; and (3) non-fluent variant, characterised by agrammatism with or without apraxia of speech. Speech and language therapists (SLTs) play a crucial role in the diagnostic process and in setting a therapeutic path along with monitoring the evolution of the clinical picture. Despite growing evidence supporting the benef

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📋 Eligibility rules (as published)
Inclusion Criteria: * Diagnosis of PPA according to the current clinical criteria (Gorno-Tempini et al., 2011) * Mild PPA defined using the Progressive Aphasia Severity Scale (PASS) * Age between 40 and 85 years * Patients with Italian mother tongue * Patients with the ability to sign the informed consent * Patients with the ability to comply with the study procedures * Patients with stable pharmacological treatment for at least 4 weeks. Exclusion Criteria: * Mini-Mental State Exam (MMSE) Score \<15 * Presence of other neurological or psychiatric diseases, including cerebrovascular disease * Severe and uncorrected hearing loss or visual disturbances * Inability to repeat multi-syllable words (4 syllables) * Concurrent participation in other pharmacological and non-pharmacological experimental studies
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What it tests

  • Behavioral Treatment
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Where

2 sites
Istituti Clinici Scientifici Maugeri IRCCS
Bari, Italy
IRCCS Ospedale San Raffaele
Milan, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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