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Intermittent Theta-Burst Stimulation to Improve Negative Symptoms and Cognition in Schizophrenia

RecruitingNAAges 18 Years - 65 YearsAllHannover Medical School
NCT06740747 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The planned randomized, sham-controlled, double-blind, monocentric study aims to evaluate the effectiveness of intermittent Theta-Burst Stimulation (iTBS) on negative symptoms and cognitive deficits in schizophrenia. Both the cerebellar vermis and the left dorsolateral prefrontal cortex will be stimulated successively within the same session. The goal of this trial is to learn if intermittent theta-burst stimulation (iTBS) of the cerebellum and the left dorsolateral prefrontal cortext (DLPFC) can treat negative symptoms and improve cognition in patients with schizophrenia. The main question it aims to answer is: Does iTBS of the cerebellum and the left DLPFC improve negative symptoms in patients with schizophrenia? Researchers will compare iTBS to sham stimulation to see if iTBS improves negative symptoms. Participants will: * Receive 10 sessions of iTBS over the course of 2 weeks *

Sign in to get the eligibility rules as simple questions to take to your doctor.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Diagnosis of schizophrenia (ICD-10: F20.-) * Age: 18-65 years * Ability to give informed consent * Signed informed consent form Exclusion Criteria: * Any electronic implants * Non-MRI-compatible metal implants (e.g., pacemaker, cochlear implant, insulin pump, metal fragment injuries, work in the metal-processing industry) * Non-TMS-compatible metal implants (compatible items include: earrings, piercings, dental fillings, crowns, implants) * Claustrophobia * Epilepsy * History of traumatic brain injury within the last 3 months * History of stroke * Active central nervous system (CNS) infection * History of CNS infection within the last 3 months * Pregnancy * Current drug, medication, or alcohol abuse * Simultaneous participation in another clinical trial * Planned changes in psychopharmacological medication within the next 2 weeks * Severe physical illnesses that could endanger the patient, affect the examinations or make the MRI scanning cause additional burden
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What it tests

  • Intermittent theta-burst stimulation
  • Sham intermittent theta-burst stimulation
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Where

1 site
Hannover Medical School
Hanover, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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