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Apixaban Prophylaxis for Prevention of Left Ventricular Thrombus Following Anterior Myocardial Infarction

RecruitingPhase 3Ages 18 Years - 75 YearsAllNational Institute of Cardiovascular Diseases, Pa…
NCT06742567 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The objective of this randomized controlled trial is to compare the safety and efficacy of low dose Apixaban (2.5 mg bid) in addition to guideline directed medical therapy vs guideline directed medical therapy alone in the prevention of left ventricular thrombus formation (after 30-days) following primary PCI in patients with acute anterior myocardial infarction with severe LV dysfunction.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged 18-65 years * Presenting with acute anterior STEMI * Severe LV dysfunction (EF\<35%) with antero-apical akinesis, dyskinesis, or aneurysm * WIHTOUT evidence of LV thrombus. Exclusion Criteria: * Patients with previous anterior myocardial infarction or LAD revascularization procedures * Patients with cardiogenic shock * Patients with LV thrombus * Patients with advanced CKD (Cr \> 2 and those on hemodialysis) * Recent ICH or major bleed requiring transfusion, low platelet counts \<100,000 * History of recent CVA ( within past three months) * Patients with atrial fibrillation or other indications for chronic anticoagulation * Pregnant patients and those with hematological disorders
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What it tests

  • Apixaban 2.5 MG PO BID
  • Control (Standard treatment)
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Where

1 site
NICVD Pakistan
Karachi, Pakistan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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