🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Flexibility, Resistance, Aerobic, Movement Execution Training in Adults With Hereditary Spastic Paraplegia

RecruitingNAAges 18 Years - anyAllIRCCS Eugenio Medea
NCT06742697 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Hereditary Spastic Paraplegia (HSP) is a diverse group of genetic neurological conditions causing progressive weakness and spasticity in the lower limbs, severely reducing balance and gait capabilities. There is currently a lack of structured neurorehabilitation programs aimed at improving gait in adults with HSP. This protocol seeks to assess the feasibility and effectiveness of a structured training approach focusing on flexibility, muscle strength, motor control, balance, and aerobic capacity. To this end, twenty adults diagnosed with HSP will engage in 10 to 16 sessions, each lasting 60 to 120 minutes, guided by a therapist once or twice a week, depending on individual preferences. At the end of the program, participants will receive a transfer package, including written instructions (a manual) and video tutorials, to encourage ongoing exercise at home. Assessments will occur before

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Adults diagnosed with Hereditary Spastic Paraplegia. * Presence of any functional deficit in the lower limbs that affects walking, such as muscle weakness, hypertonia, or balance issues. * Ability to walk without the need for physical contact with another person, as defined by a Functional Ambulation Category score of 3 or higher. * Ability to understand simple instructions, comprehend the purpose of the study, willingness to participate and undergo at least 10 treatment sessions, eligible and willing to sign the informed consent. Exclusion Criteria: * Botulinum toxin or surgery to treat lower limb hypertonia in the six months prior to enrollment in the study. * Contraindications for moderate physical activity, such as stretching exercises, muscle strength training, and aerobic capacity training.
💊

What it tests

  • Flexibility, Resistance, Aerobic, Movement Execution training
📍

Where

2 sites
Scientific Institute, IRCCS E. Medea, Department of Bosisio Parini, Lecco, Italy.
Bosisio Parini, Italy
Scientific Institute, IRCCS E. Medea, Department of Pieve di Soligo, Treviso, Italy
Pieve di Soligo, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy