A Clinical Study of Ultra-transplantation for the Treatment of Major Thalassemia Scheme

Patient inclusion criteria : * Diagnosed with severe Mediterranean anemia, with no restrictions on alpha and beta types; * Age between 7-12 years old, male or female not limited; Weight\<40kg * The patient has or does not have HLA matched or semi matched donors, but unconditionally transplants or refuses to undergo blood stem cell transplantation treatment; And patients who unconditionally or refuse to undergo gene therapy for thalassemia; * There are HLA matched or mismatched donors who meet the donor criteria through physical examination; * The patient and their family agree to receive super transplantation treatment and sign a written informed consent form before the transplantation trial. （2） Exclusion criteria for patients: * Psychiatric patients; * Participants in clinical trials of other drugs within the past month; * There are no suitable HLA mismatched donors available. * Other researchers have determined that they are not suitable to participate in this study. （3） Supplier screening criteria: * HLA typing matches the patient's haplotype * KIR configuration * NIMA * DSA negative * Routine physical examination * Genetic screening for carriers of thalassemia, mild or no carriers of thalassemia * Sign the informed consent form.