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Efficacy of Montelukast in Preventing Transaminase Elevation in Adult Dengue Patients

RecruitingPhase 2, Phase 3Ages 20 Years - anyAllPhramongkutklao College of Medicine and Hospital
NCT06747130 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn if drug montelukast works to treat dengue in adults. It will also learn about the safety of drug montelukast . The main questions it aims to answer are: Does drug montelukast lower the incidence of liver enzyme elevations in participants ? What medical problems do participants have when taking drug montelukast ?

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient age \>18 years * Dengue infection diagnosed by NS1 antigen, or polymerase chain reaction * Admitted to the hospital * Written informed consent from patient or attending relative able to and willing to give informed consent Exclusion Criteria: * Other possible cause of fever other than dengue infection * Pregnancy * Unable to take medication * Aminotransferase level above 150 U/l * Allergy to paracetamol or tramadol * Paracetamol indicated for condition other than dengue infection * Critically ill patient who need ICU or invasive ventilation support * History of cirrhosis * Unable to communicate * Other indication of montelukast * History of psychiatric illness
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What it tests

  • Montelukast
  • Montelukast Placebo
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Where

1 site
Phramongkutklao Hospital
Bangkok, Thailand
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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