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Cognitive Behavioral Therapy for Sleep and Circadian Disturbances (CBT-I) in Treatment-Resistant Schizophrenia

RecruitingNAAges 18 Years - 64 YearsAllJimmi Nielsen
NCT06749444 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Using a randomized controlled design, the project aims to test if cognitive behavioral therapy interventions specifically targeting sleep disorders can significantly lessen the burden of the disrupted sleep in patients with treatment resistant schizophrenia (TRS) and by proxy lead to a reduction in psychotic symptoms and improvement in quality of life. We are including treatment-resistant patients with schizophrenia other nonorganic and chronic psychoses and in addition meeting the criteria of a sleep or circadian disorder. Included patients will be block randomized to either 8-10 sessions of CBT-I (active treatment) with a specific focus on sleep or 8-10 sessions of regularCBT with a specific focus on patients' psychopathology (treatment as usual) approx.1 session/week. After 12 weeks the full battery of assessments will be repeated forboth groups. Primary analyses will be to identify

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📋 Eligibility rules (as published)
Inclusion Criteria: * Diagnosed with ICD-10 schizophrenia (DF20), chronic paranoid psychosis (DF22), schizo-affective disorder (DF25) or other non-organic psychosis (DF28-DF29) * Treatment resistance according to TRRIP criteria * Sleeping difficulties (minimum duration 3 months) * ISI score \>14 * Stable psychopharmacological treatment the last month * Only legal competent patient can participant Exclusion Criteria: * Psychiatric admission last six months (more than 1 week or resulted in significant changes in psychopharmacological treatment) * Substance abuse to a degree that will interfere with participation. * Diagnoses of sleep apnea/CPAP use
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What it tests

  • CBT-I
  • CBT
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Where

1 site
Mental Health Centre Glostrup
Glostrup, Denmark, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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