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The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units?

Recruitingn/aAges 18 Years - anyAllJena University Hospital
NCT06749483 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Here, the investigators propose to study host responses to reduced microbiome complexity driven by treatment with broad spectrum antibiotics in patients with severe infections or sepsis. The proposal aims to combine holistic approaches with emerging experimental technologies to investigate the complex interactions between the gut microbiota and its host and assess the impact of specific bacterial communities on longevity and stress responses. A strong focus of this study will also be placed on microbiome dysbiosis and secondary impacts on short- and long-term brain dysfunction using clinical, laboratory and imaging procedures.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years * One of the following criteria 1. Critically ill patients treated with meropenem or piperacillin/tazobactam started within the last 72 h 2. Critically ill patients without systemic antimicrobial therapy within the last 72 hours and an expected ICU length of stay of more than 3 days 3. Long-term survivors of sepsis, e.g. from pre-existing sepsis cohorts Exclusion Criteria: * Inflammatory bowel disease * Major bowel resection * Selective decontamination of the oral and digestive tract * Oral vancomycin therapy * Immunocompromised patients * History of chemotherapy during the last 6 months. * Known travel history to countries to areas of high antimicrobial resistance (\>5% according to the report of the European Centre for Disease Prevention and Control and all countries except USA and Canada) within the last 4 weeks * Acute neurological diseases (e.g., brain ischemia, hemorrhage, meningoencephalitis, tumor) * Manifest dementia, pre-existing psychiatric diseases (schizophrenia, psychosis) * Acute brain surgery * MRI contraindications: pacemakers, hearing aids, neurostimulation, insulin pumps, other potentially ferromagnetic implants, screws, clips, prostheses, metal splinters, etc., pregnancy, claustrophobia, extensive tattoos.
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What it tests

  • Not listed
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Where

1 site
Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Jena
Jena, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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