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Comparative Efficacy of Intra-articular vs. MRI-guided Extra-articular Dextrose Injections in Knee Osteoarthritis Management

RecruitingNAAges 45 Years - 80 YearsAllShin Kong Wu Ho-Su Memorial Hospital
NCT06755697 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Osteoarthritis (OA) is a serious worldwide public health concern, causing increased disability-adjusted life years (DALY), the reasons of which include rising prevalence of obesity and increasing older populations. The knee is one of the most easily injured joint in the body, and knee OA can become a chronic and disabling condition that pose a threat to not only the patient but also his or her caretakers and healthcare resources. The prevalence of knee OA is 5% - 15% in men over 60 years, and 10% - 25% in women aged more than 60. Knee OA can result from injuries, diseases, or wear and tear from overuse. It refers to structural changes that affect subchondral bone, articular cartilage, menisci, ligaments, synovium, and other joint structures. Currently, there are several conservative management of knee OA, including physiotherapy (therapeutic exercise, diathermy, electrotherapy), oral or

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. . age between 45 to 80 years old; 2. . meet at least three of the six American College of Rheumatology (ACR) criteria, including age over 50 years, morning stiffness less than 30 minutes, crepitus in passive knee movements, bony tenderness, bony enlargement, and no palpable warmth; 3. . radiologic grading of 2 or 3 according to Kellgren-Lawrence criteria; 4. showing willingness to receive prolotherapy. Exclusion Criteria: 1. . severe systemic disorders including cancer, uncontrolled diabetes mellitus, sepsis, or cardiopulmonary diseases; 2. . history of anticoagulation therapy, knee injection over the past three months; 3. . history of knee surgery or candidates for knee arthroplasty; 4. . history of drug abuse; 5. . a history of intolerance to prolotherapy; 6. . pregnancy; 7. . infectious arthritis, inflammatory joint diseases, joint dysplasia; 8. Body Mass Index (BMI) greater than 35 kg/m2; 9. . not suitable or no willing to received MRI examination of the knee.
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What it tests

  • Intra-articular US-guided hypertonic dextrose injection, IA group
  • Extra-articular US-guided injection targeting MRI-positive lesion sites, EA group.
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Where

1 site
Shin Kong Wu Ho-Su Memorial Hospital
Taipei, Taiwan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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