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CT-95 in Advanced Cancers Associated With Mesothelin Expression

RecruitingPhase 1Ages 18 Years - anyAllContext Therapeutics Inc.
NCT06756035 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a Phase 1a/1b, first-in-human (FIH), open-label, multi-center dose escalation and expansion study of the safety, pharmacokinetics (PK), pharmacodynamics, and antitumor activity of single-agent CT-95 in subjects with advanced (recurrent, unresectable, or metastatic) cancers associated with MSLN expression.

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📋 Eligibility rules (as published)
Inclusion Criteria: * ECOG 0 or 1 * Subjects with evaluable disease per RECIST 1.1 or mRECIST * Subjects with adequate organ function. * Subjects with advanced cancers associated with mesothelin expression Exclusion Criteria: * Uncontrolled significant active infection or any medical or other condition that in opinion of the investigator would preclude the subject's participation in the study. * Prior treatment with MSLN-targeted CD3 or chimeric antigen receptor T cell (CAR-T) therapy * Concurrent participation in another investigational clinical trial. * Evidence of leptomeningeal disease
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What it tests

  • CT-95
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Where

9 sites
Context Investigational Site
Denver, United States
Context Investigational Site
Chicago, United States
Context Investigational Site
Grand Rapids, United States
Context Investigational Site
Hackensack, United States
University of Pennsylvania
Philadelphia, United States
Context Investigational Site
Philadelphia, United States
Context Investigational Site
Nashville, United States
Context Investigational Site
San Antonio, United States

…and 1 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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