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Efficacy and Olfactory Network of Electro-acupuncture for Subjective Cognitive Decline

RecruitingNAAges 55 Years - 79 YearsAllThe Affiliated Nanjing Drum Tower Hospital of Nan…
NCT06758154 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Subjective cognitive decline (SCD) is the early diagnosis and treatment window period of Alzheimer's disease (AD), and the identification of SCD individuals who will progress to AD (pSCD) is a research hotspot. Based on olfactory fMRI,previous studies have found that SCD individuals showed damaged entorhinal neural circuits. After follow-up, the incidence of pSCD increased by three times. But,the spatiotemporal characteristics of the entorhinal neural circuits and whether it has the value of individualized prediction and intervention target need to be further studied. Thus, based on multi-center ambispective cohort study at home and abroad, we will (1) build a new paradigm of synchronous fMRI-EEG olfactory task state Oddball experiment, jointly representational similarity analysis, extract spatiotemporal characteristics of neural circuits damage, and discover and verify that the entorhin

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Meet the diagnostic criteria for SCD diseases; 2. 55-79 years old; 3. ≥8 years of schooling; 4. Right-handed; 5. Sign the informed consent. Exclusion Criteria: 1. Have received other antidepressant therapy or involved in other clinical trials in the previous 2weeks. 2. Infarct located in the left DLPFC. 3. Positive psychiatric history and major trauma exposure history, such as depression, epilepsy, etc., in the past. 4. Other serious concomitant diseases (aphasia, severe edema, venous thrombosis, arteriosclerosis occlusion, diabetic vascular disease, peripheral neuropathy, spinal lesions, brain trauma, intracranial infection, brain tumors, etc.) or secondary diseases (heart, liver, renal failure, etc.). 5. Infection around acupoints and/or intolerance to acupuncture manipulation. 6. MRI or rTMS contraindications (claustrophobia, metal implants, cochlear implants, impulsator, etc.).
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What it tests

  • "TXJN" electro-acupuncture
  • sham acupuncture
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Where

1 site
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Nanjing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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