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Characterizing the Retinal Microvasculature in Patients with Fabry Disease: a Prospective Observational Study

Recruitingn/aAges 18 Years - anyAllTechnical University of Munich
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In plain words

What the trial is, and whether it could suit you

This study aims to gain a deeper understanding of endothelial dysfunction in patients with Fabry disease through a prospective study of the retinal microvasculature and to identify an objective, non-invasive marker to assess disease severity and cardiovascular risk in patients. The main questions addressed are: Do dynamic and static retinal vessel analysis parameters differ from those in healthy individuals? Can these parameters predict cardiovascular and/or Fabry-related events during follow-up? Do these parameters change during follow-up in patients with a non-stable disease?

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Age \> 18 years * Diagnosis of Fabry disease by genetic testing or GB3 activity in leukocytes. * Signed informed consent form Exclusion Criteria: * Active infection or cancer * Surgery less than 2 weeks prior to inclusion in the study * Known glaucoma * Lack of capacity to give consent; lack of informed consent. * Known epilepsy
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What it tests

  • Dynamic retinal vessel analysis (DVA)
  • Biochemistry and immune phenotyping
  • Questionnaires (Patient reported outcomes)
  • Cardio MRI
  • Optical coherence tomography (OCT)
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Where

1 site
Department of nephrology, Klinikum rechts der Isar
Mรผnchen, Germany
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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