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An Interventional Pilot Study on the Effect of Extra Virgin Olive Oil on Women with Preeclampsia Risk

RecruitingNAAges 18 Years - 45 YearsFemaleYaniv Ovadia
NCT06759545 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study explores the potential benefits of Extra Virgin Olive Oil from early harvested olives (EVOOEH) in reducing the risk of preeclampsia (PE) in high-risk pregnant women. EVOO, particularly EVOOEH, is rich in antioxidant compounds, including polyphenols, which may help improve vascular health and reduce oxidative stress, potentially preventing complications like PE. The hypothesis is that EVOOEH may reduce microvascular damage, improve placentation, and prevent dysglycemia, ultimately lowering the risk of PE and gestational diabetes mellitus (GDM). The primary objective of this intervention is to evaluate the effect of EVOOEH on PE incidence during pregnancy, specifically assessing the impact on markers of PE, GDM, and other pregnancy-related outcomes. The study is designed as an interventional, randomized, parallel-assignment dietary trial involving 156 pregnant women at high ris

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📋 Eligibility rules (as published)
Inclusion Criteria: * Pregnant women with clinical risk factors for PE \[previous PE, primigravida, chronic hypertension, chronic renal disease, autoimmune disease (systemic lupus erythematosus, antiphospholipid antibody syndrome), overweight (BMI\>30), obesity (BMI\>35), morbid obesity (BMI\>40), presentational diabetes (type 1 or type 2), multiple pregnancy\]. * gestational ages of 8 to 16 weeks attending Barzilai University Medical Center at Ashkelon (BUMCA). Exclusion Criteria: • Refusing enrollment or participation.
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What it tests

  • Dietary MOH recommendations and daily addition of 42 ml (three tablespoon) at each morning of EVOOEH
  • Dietary MOH recommendations
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Where

1 site
Barzilai University Medical Center
Ashkelon, Israel
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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