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Comparing FET Guided by ERA Vs Standard Timing in Patients with Recurrent Implantation Failure

RecruitingNAAges 18 Years - 40 YearsFemaleThe University of Hong Kong
NCT06762626 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The pregnancy rate of in vitro fertilisation (IVF) remains around 35% per transfer. Women who are not pregnant following several embryo transfers are regarded as having recurrent implantation failure (RIF), with one of the causes being the asynchronization of the embryo and endometrium. Endometrial receptivity analysis (ERA) may identify the window of implantation and guide the timing of embryo transfer to improve the pregnancy outcomes. However, there is no randomized controlled trial on the clinical effectiveness of ERA in women with RIF. This is a multicenter double-blind randomized controlled trial. All participants will have an endometrial biopsy for ERA in a standard hormonal treatment cycle. They will then be randomly assigned in the central laboratory into the intervention or control group in a 1:1 ratio. At the transfer cycle, participants in the intervention group will have fr

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Women with recurrent implantation failure 2. Women aged \< 40 years 3. Body mass index of women between 18.5 (inclusive) and 30 (exclusive) kg/m² 4. Women with at least one high quality frozen blastocyst (BB grade or above) and planning to undergo a single blastocyst transfer 5. Women who will give written informed consent Exclusion Criteria: 1. Women with recurrent pregnancy loss (3 or more biochemical or spontaneous miscarriages) 2. Either partner with known chromosomal abnormalities including balanced translocations 3. Women undergoing preimplantation genetic testing 4. Women with endometrial thickness \< 7 mm in the IVF cycle 5. Women with a confirmed diagnosis of stage III-IV endometriosis or adenomyosis affecting uterine cavity morphology 6. Women with a confirmed diagnosis of antiphospholipid syndrome 7. Pathologies affecting the uterine cavity, including polyps, submucosal fibroids, intramural fibroids \> 4 cm, or hydrosalpinx
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What it tests

  • Frozen embryo transfer according to endometrial receptivity analysis result
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Where

1 site
The University of Hong Kong
Hong Kong, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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