🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Sacral Neuromodulation and Faecal Incontinence and Its Unknown Effect on the External Anal Sphincter

Recruitingn/aAges 18 Years - anyAllUmeå University
NCT06763861 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

This innovative project aims to investigate structures and morphology of the external anal sphincter (EAS) as well as the impact of sacral neuromodulation (SNM) on the EAS morphology and biochemistry among patients with faecal incontinence (FI). SNM is a well implemented treatment for FI and consist of electrical stimulation of sacral nerve roots to promote continence and may even contribute to total continence. It has shown a positive effects on both short- and long-term. The biologic effect of SNM on EAS is unknown. The aim is to investigate the effect of SNM on EAS morphology, function, and biochemistry to help physicians and researchers to understand the underlying mechanisms of SNM and the anal sphincter complex to further improve and optimize treatment methods for patients with FI. The research project consists of three phases. The first phase includes biopsies from the EAS amon

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Phase 1 Inclusion Criteria: * ≥ 18 years of age * Male or female * Diagnosed with rectal cancer and receive treatment with abdominoperineal resection * Signed an informed consent Exclusion Criteria: * Previous diagnosis of FI * Unable to speak and/or read Swedish to ensure informed consent * Tumour involving the sphincter complex or is in close connection Phase 2 and 3 Inclusion Criteria: * Diagnosed with FI and will receive treatment with sacral neuromodulation * Male or female * Signed an informed consent Exclusion Criteria: * Unable to speak and/or read Swedish to ensure informed consent
💊

What it tests

  • Biopsy
📍

Where

1 site
Umeå University Hospital
Umeå, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy