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Effect of Goal-directed Analgesia and Sedation Using EEG Derived QCON/qNOX in ICU Patients

RecruitingNAAges 18 Years - 90 YearsAllUniversità degli Studi di Ferrara
NCT06769308 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Sedation and analgesia are fundamental tools for managing critical patients who require mechanical ventilation. However, recent scientific literature highlights that excessive sedation in these patients can increase the duration of mechanical ventilation and extend the overall length of stay in intensive care, as well as expose them to a higher risk of hypotension, venous thrombosis, and nosocomial pneumonia. The titration of sedation and analgesia in intensive care, on the other hand, is currently based primarily on clinical parameters (such as the onset of delirium, asynchronies with the ventilator, for example), which can lead to treatments not proportionate to the patient's needs. The present study aims to evaluate the application, in an intensive care setting, of the Conox® system, a device already widely used in monitoring the anesthetic plan in the operating room. This tool would

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📋 Eligibility rules (as published)
Inclusion Criteria: Age 18-90 years Admission to the ICU for less than 24 hours Expected mechanical ventilation for \>48 hours Ongoing sedation Exclusion Criteria: Mechanical ventilation (MV) for less than 48 hours Patient or next of kin refusal to participate BMI \> 35 Cerebrovascular disease Scheduled surgery Neuromuscular disease Presence of craniofacial trauma that prevents the placement of electrodes
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What it tests

  • Sedation titration according to qEEG
  • Sedation titration according to standard of care
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Where

2 sites
Azienda Ospedaliera Universitaria Sant'Anna
Ferrara, Italy
Azienda Ospedaliera Universitaria Federico II - "Policlinico"
Naples, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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