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Effect of Subanesthetic Dose of Esketamine on Sleep Quality

RecruitingNAAges 18 Years - 65 YearsFemaleNanjing First Hospital, Nanjing Medical University
NCT06773143 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to explore whether subanesthetic doses of esketamine can improve the sleep quality of patients undergoing modified radical mastectomy for breast cancer. In this study, 184 people are expected to participate from admission to three days after surgery. The process requires participants to cooperate with the completion of the digital rating scale, the Athens Insomnia Scale, the Visual Analog Pain Rating Scale, the Hospital Anxiety and Depression Rating Scale, and the collection of venous blood for research indicators (IL-6, TNF-ฮฑ, cor, BDNF). If participants agree to participate in this study, the investigators will assign a unique identification number to each participant and create a medical record for participants. One day before surgery, the investigators will conduct assessments using the Athens Insomnia Scale, the Visual Analog Pain Rating Scale,

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Patients diagnosed with breast cancer by pathology and immunohistochemistry 2. Patients receiving neoadjuvant chemotherapy 3. Age 18 to 65 years old; d) ; 4. ASA grade โ…  - โ…ข 5. BMI 18 to 30 kg/m2 Exclusion Criteria: * 1: Patients refuse to participate in the study 2: BMI \> 30 kg/m2 3: Recent history of drug abuse 4: Allergy to or contraindications to esketamine 5: Cognitive dysfunction or inability to communicate 6: Severe dysfunction of important organs such as liver and kidney function
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What it tests

  • Esketamine at low dose
  • Normal Saline (0.9% NaCl)
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Where

1 site
Nanjing First Hospital
Nanjing, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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