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Analgesic Efficacy of Intravenous Ketamine as a Continuous Infusion vs PCA in the Management of Acute Postoperative Pain in Major Orthopedic Surgery.

RecruitingPhase 4Ages 18 Years - anyAllUniversidad de Antioquia
NCT06774274 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to determine whether treating pain after surgery with ketamine is more effective when administered intravenously as a continuous infusion or through a patient-controlled analgesia (PCA) pump. This study focuses on adult volunteers following major orthopedic surgery. We have two main questions to address: * Is a continuous intravenous infusion of ketamine as effective as ketamine administered through a PCA pump for managing pain after major orthopedic surgery. * Does a continuous intravenous infusion of ketamine result in lower opioid requirements compared to ketamine delivered through a PCA pump for pain management after major orthopedic surgery? Participants will be divided into two groups. One group will receive ketamine via continuous infusion, while the other will receive it through a PCA pump. Both groups will also receive a placebo (a substance

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients over 18 years of age * Elective major orthopedic surgery. * ASA (American Association of Anesthesiology) classification 1, 2 or 3. Exclusion Criteria: * Patients with a diagnosis of perioperative kidney injury or hepatic failure * Patients with active cardiac conditions * Patients with any cognitive impairment that disables the patient from operating the PCA pump or impedes the postoperative interview * Patients with scheduled ICU admission with invasive ventilatory support * Patients with known hypersensitivity to opioid medications * Patients with past medical history of severe adverse reactions to opioids or ketamine. * Pregnant patients * Patients undergoing continuous regional anesthetic techniques including peripheral nerve catheters or continuous epidural catheters * Patient refusal to participate in the study
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What it tests

  • Ketamine infusion
  • PCA Ketamine
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Where

1 site
St. Vincent's Foundation University Hospital
Medellín, Colombia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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